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NIH鈥檚 High-Risk, High-Reward Research program to fund Sabrina Spencer鈥檚 精品SM在线影片 research that could shed light on cancer treatment

Scientists do not fully understand how cells choose between proliferation and quiescence (a state of non-proliferation) but a 精品SM在线影片 biochemist鈥檚 novel proposal to study the issue has won the support of the National Institutes of Health (NIH).

Sabrina Spencer, 精品SM在线影片 assistant professor of biochemistry, is one of听58 scientists nationwide to have won an NIH Director鈥檚 New Innovator Award. Those awards, announced today, are part of the听High-Risk, High-Reward Research program, which supports 鈥渆xtraordinarily creative scientists proposing highly innovative research to address major challenges in biomedical research.鈥� Zoe Donaldson,听an assistant professor of behavioral neuroscience at 精品SM在线影片, also won a Director's New Innovator Award. (Read more about Donaldson's research.)

Spencer鈥檚 proposal is unconventional because it 鈥渃hallenges textbook dogma,鈥� she said.

Spencer noted that significant scientific research effort in the 1980s and 鈥�90s was devoted to understanding how cells enter proliferation from a quiescent state induced by cell starvation.听听After having reached a well-accepted set of conclusions, researchers subsequently shifted their attention elsewhere, Spencer said.

Today, however, Spencer proposes to revisit some of these conclusions using new cutting-edge tools, including state-of-the-art single-cell technology that enables scientists to measure cellular activity by time-lapse microscopy without starving or otherwise disturbing the cells. She plans to combine her experimental observation with high-powered computational analyses of the time-lapse movies.听

鈥淭hese technological advances will lead to fundamental knowledge about cell-cycle regulation, while also potentially revealing medically relevant interventions for controlling the proliferation-quiescence decision in cancer,鈥� she writes in her NIH abstract.听

罢丑别听, the nation's medical research agency, includes 27 institutes and centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases.听

The High-Risk, High-Reward Research program supports ideas with potential for great impact in biomedical research from across the broad scope of the NIH, such as听exploring how the brain and immune system communicate with one another, identifying proteins involved in organ-to-organ communication, using breast milk to deliver therapies to infants, and determining the public health consequences of urban growth.听

The program catalyzes scientific discovery by supporting exciting, high-risk research proposals that may struggle in the traditional peer-review process despite their transformative potential. Program applicants are encouraged to pursue creative, trailblazing ideas in any area of research relevant to the NIH mission.

The awards total approximately $282 million over five years, pending available funds. Spencer鈥檚 award is $1.5 million.听

罢丑别听NIH Director鈥檚 New Innovator Award, established in 2007, supports unusually innovative research from early career investigators who are within 10 years of their final degree or clinical residency and have not yet received a research project grant or equivalent NIH grant.

Jim Goodrich, professor and chair of the 精品SM在线影片 Department of Biochemistry, noted that the Director鈥檚 New Innovator Award is a 鈥渉ighly prestigious, major research award鈥� that will allow Spencer to pursue a creative and innovative line of research.听

鈥淭his research could enhance the ability to predict and improve the response of cancer cells to drug treatments that block proliferation,鈥� Goodrich said.

Spencer is honored to receive this award and the funding that comes with it. Additionally, she said, 鈥淚f you look at the past winners of this award, and see where they are now and what they鈥檝e done, it鈥檚 a very exciting group of people鈥� The best part will be meeting and exchanging ideas with the other New Innovator Award recipients.鈥�

Spencer holds a PhD in computational and systems biology from the Massachusetts Institute of Technology, an MS in human genetics from the University of Michigan at Ann Arbor, and bachelors鈥� degrees in biology and French language and literature from The George Washington University.听

She joined the 精品SM在线影片 faculty in 2014 and is an associate member of the CU Cancer Center and a member of the BioFrontiers Institute.