C. WyattShields IV

  • Assistant Professor
  • CHEMICAL AND BIOLOGICAL ENGINEERING
  • BIOMEDICAL ENGINEERING PROGRAM
  • MATERIALS SCIENCE AND ENGINEERING PROGRAM
Address

Office: JSCBB D218

Education

PhD, Duke University, Biomedical Engineering (2016)
BS, University of Virginia, Biomedical Engineering (2011)

Awards

  • Camille Dreyfus Teacher-Scholar Award (2024)
  • Emerging Investigator,听Nanoscale听(2024)
  • Outstanding Junior Faculty Award, Department of Chemical and Biological Engineering (2023)
  • Frontiers of Engineering Participant, National Academy of Engineering (2023)
  • Packard Foundation Fellowship in Science and Engineering (2022)
  • NIH Maximizing Investigators' Research Award (MIRA) (2022)
  • Pew Biomedical Scholar (2022)
  • ONR Young Investigator Program Award (2022)
  • NSF CAREER Award (2022)
  • Beckman Young Investigator Award Finalist (2021)
  • Best On-Demand Talk from the Controlled Release Society (2020)
  • Dean鈥檚 Award for Excellence in Mentoring, Duke University (2016)
  • Exceptional Student Award, ISAC at CYTO (2015)
  • NSF Graduate Research Opportunities Worldwide听(2014)
  • Exceptional Student Award,听ISAC at CYTO (2013)
  • NSF Graduate Research Fellowship (2012)

Selected Publications

  • Lee, JG;* Thome, CP;* Cruse, ZA; Ganguly, A; Gupta, A; Shields IV, CW. 鈥淢agnetically locked Janus particle clusters with orientation-dependent motion in AC electric fields鈥 Nanoscale 2023. 40(15): 16268鈥16276. (*co-first authors). DOI:听.听
  • Lee, JG;* Raj, RR;* Day, NB;* Shields IV, CW. 鈥淢icrorobots for biomedicine: Unsolved challenges and opportunities for translation鈥 ACS Nano 2023. 17(15): 14196鈥14204. (*co-first authors). DOI:听.听
  • Shields IV, CW. 鈥淏iohybrid microrobots for enhancing adoptive cell transfers鈥 Accounts of Materials Research2023. 4(7): 566鈥569. DOI:听.听
  • Lee, JG; Raj, RR; Thome, CP; Day, NB; Martinez, P; Bottenus, N; Gupta, A; Shields IV, CW. 鈥淏ubble-based microrobots with rapid circular motions for epithelial pinning and drug delivery鈥 Small 2023. 19(32): 2300409. DOI:听.听
  • Thome, CP; Hoertdoerfer, WS; Bendorf, J; Lee, JG; Shields IV, CW. 鈥淓lectrokinetic active particles for motion-based biomolecule detection鈥 Nano Letters听2023. 23(6): 2379鈥2387. DOI:听.听
  • Day, NB; Dalhuisen, R; Loomis, NE; Adzema, SG; Prakash, J; Shields IV, CW. 鈥淭issue-adhesive hydrogel for multimodal drug release to immune cells in skin鈥 Acta Biomaterialia 2022. 150: 211鈥220. DOI:听.
  • Tanjeem, N; Minnis, MB; Hayward, RC; Shields IV, CW. 鈥淪hape-changing particles: From materials design and mechanisms to implementation鈥 Advanced Materials听2022. 3(34): 2105758. DOI:听.
  • Day, NB; Wixson, WC; Shields IV, CW. 鈥淢agnetic systems for cancer immunotherapy鈥 Acta Pharmaceutica Sinica B 2021. 11(8): 2172鈥2196. DOI:听.听
  • Shields IV, CW; Kim, YK; Han, K; Murphy, AC; Scott, AJ; Abbot, NL; Velev, OD. 鈥淐ontrol of the folding dynamics of self-reconfiguring magnetic microbots by using liquid crystallinity鈥澨Advanced Intelligent Systems听2020. 2(2): 1900114. DOI:听.听
  • Shields IV, CW; Evans, MA; Wang, LLW; Baugh, N; Iyer, S; Wu, D; Zhao, Z; Pusuluri, A; Ukidve, U; Pan, D; Mitragotri, S. 鈥淐ellular backpacks for macrophage immunotherapy鈥澨Science Advances听2020. 6(18): eaaz6579. DOI:听.

Research Interests

Drug Delivery, Biosensing,听Active Matter,听Soft Materials, Colloid and Interface Science, Microfluidics

Our group is broadly interested in biosensing and drug delivery. The distinguishing approach we take is through engineering particle systems, especially those that interface with biology and controllably respond to external stimuli.听We work听at the intersection of materials, soft matter physics and bioengineering to rationally design colloidal and supracolloidal particles for a range of applications.听We take inspiration from nature, which efficiently assembles matter across length scales that encode a rich variety of behaviors when stimulated by energy.听We have three guiding objectives, to: 1) understand how particles interact in and out of equilibrium and, in turn, how to control their behaviors by tailoring their nano and microscale properties such as shape, size and composition; 2) apply new insights to create collections of "smart" particles that perform useful tasks such as actuate and release encapsulated payloads; and 3) integrate our pipeline of new materials听to advance biosensing and drug delivery by developing new diagnostic and therapeutic platforms for a variety of indications.听

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