Mark Rentschler

Borden, Rentschler inducted into the AIMBE College of Fellows

Alexander James Servantez — Mon, 31 Mar 2025 19:24:59 +0000

Borden, Rentschler inducted into the AIMBE College of Fellows Alexander Jame… Mon, 03/31/2025 - 13:24

Professors Mark Borden and Mark Rentschler have been inducted into the American Institute for Medical and Biological Engineering (AIMBE) College of Fellows. The program is among the highest professional distinctions given to medical and biological engineers, representing the top 2% of these engineers around the world.

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Rentschler, Aspero Medical awarded $4.5M for endoscopy advancement

Alexander James Servantez — Tue, 11 Feb 2025 20:48:48 +0000

Rentschler, Aspero Medical awarded $4.5M for endoscopy advancement Alexander Jame… Tue, 02/11/2025 - 13:48

Alexander Servantez

It’s been six years since the launch of startup company Aspero Medical, co-founded by Professor Mark Rentschler of the Paul M. Rady Department of Mechanical Engineering. The company has seen great success, including the development of a medical device designed to enable more efficient procedures in the small bowel region.

Today, with the help of a $4.5 million award through the Anschutz Acceleration Initiative (AAI), Rentschler and his colleagues are working to bring two new products to the market that will transform these types of procedures even further.

“We brought our first product out on the market in 2024,” said Rentschler, also a faculty member in biomedical engineering (BME) and robotics. “We are planning to bring a second and third product to the market in 12-18 months, and we are extremely excited to get these devices in the hands of interventional endoscopists.”

Professor Mark Rentschler holding Aspero Medical's patented Ancora-SB balloon overtube.

In 2023, Aspero received clearance from the Food and Drug Administration (FDA) to market and sell the Ancora-SB device. The product is used during endoscopy procedures to diagnose and treat small bowel diseases.

According to Rentschler, operating within the small intestine can be time consuming and technically challenging. Equipped with a patented micro-textured balloon, the Ancora-SB overtube is designed to provide more traction and anchoring consistency than smooth latex or smooth silicone balloon overtube competitors.

“Balloon overtubes for small bowel procedures have been around for about a decade,” said Rentschler. “We’re not looking to change the small bowel enteroscopy procedure, but instead improve balloon anchoring performance during these procedures in the small bowel.”

Ancora-SB has allowed Aspero to prove their worth in hospitals. Their next products expand on this concept, of course, with additional features that can facilitate a less invasive interventional procedure than traditional open surgery.

The next generation balloon overtube will be used to remove cancerous lesions in the large bowel region. It features an extra working channel that allows for an additional tool to be utilized alongside the visualization scope. This offers physicians more control, access, and stabilization when maneuvering through the colon and performing advanced interventional procedures.

“Conceptually, these devices will enable triangulated surgery with two tools and centralized visualization so that physicians can more efficiently perform surgery from inside the lumen,” Rentschler said. “Instead of historically invasive procedures, where the patient is cut open, and the cancerous bowel region is removed, we’re assisting physicians as they remove the cancer from the inside of the lumen during an outpatient procedure.

“It's much less invasive, with potentially tremendous cost savings, and numerous benefits for the patient.”

Aspero’s third product will be another balloon overtube, this time with a working channel that enables minimally invasive cancer removal in the esophagus and stomach regions of the gastrointestinal tract.

Rentschler showcasing all three of the medical devices in Aspero Medical's multi-product platform, including their two new highly anticipated devices.

Rentschler and his team say the two upcoming devices have the potential to replace a large, and growing, number of today’s conventional surgical procedures in the gastrointestinal region by enhancing safety and efficiency while reducing patient recovery time. Moving procedures from inpatient surgery to outpatient endoscopy can generate potential cost savings of up to 50 percent or more.

“Everyone knows this is the direction we need to go. Clinical outcomes from these types of procedures are incredibly strong, but the techniques and devices aren’t widely available yet,” said Rentschler. “We are creating products that help physicians and patients feel safe and comfortable without overcomplicating things. The paradigm is rapidly shifting, and we endeavor to push endoscopy forward.”

The company is currently finalizing the design of the second product. It’s about six months further along in development than the third product, but Rentschler says they are looking to have both devices FDA cleared by the end of 2026.

When all three devices hit the market, Aspero will look to market a portfolio of products, rather than a single tool. But further innovation is on the horizon, this time incorporating the Ancora balloon technology with a robotic element.

“Ancora is a multi-product platform focusing on the small bowel, large bowel, stomach and esophageal regions,” Rentschler said. “Our next potential venture will be in flexible robots. We’ll continue with our balloon overtubes, but as anchoring platforms to be used with flexible robotic endoscopy systems.”

Until then, Rentschler and company are full steam ahead on these next products. The $4.5 million AAI grant is being offered over a four year span, but they anticipate spending that money much sooner so they can get the devices out on the market and begin positively impacting patients and physicians everywhere.

But that’s not their only goal. With a lot of Colorado involved in the company’s revolutionizing technology, Rentschler hopes to also tell another story.

“I started Aspero Medical with Dr. Steven Edmundowicz at CU Anschutz. We’ve received a number of grants from the state of Colorado and everyone involved is invested in our vision,” said Rentschler. “We believe that a rising tide raises all boats, and when we think of Aspero, we want it to be a successful Colorado story.”

Six years ago, Professor Mark Rentschler helped launch startup company Aspero Medical to develop a medical device used during endoscopy procedures. Today, with the help of a $4.5 million grant through the Anschutz Acceleration Initiative, Rentschler and his team are bringing two new medical devices to the market that have the potential to transform surgeries in the gastrointestinal region even further.

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Faculty inducted as Senior Members of the National Academy of Inventors

Anonymous — Fri, 05 Nov 2021 14:42:44 +0000

Faculty inducted as Senior Members of the National Academy of Inventors Anonymous (not verified) Fri, 11/05/2021 - 08:42

Rachel Leuthauser

Left: Mark Rentschler
Right: Greg Rieker

Mechanical Engineering Professors Mark Rentschler and Greg Rieker are now Senior Members of the National Academy of Inventors (NAI) – an honor that recognizes their thought-leadership and discovery.

The two professors were inducted on Nov. 1, during NAI’s tenth annual meeting. NAI Senior Members are active faculty, scientists and administrators who have produced technologies that have brought, or aspire to bring, real impact to the welfare of society. They are also recognized for educating and mentoring the next generation of inventors.

Rentschler’s patent success can be seen at his medical device startup Aspero Medical. The company recently received a patent for medical balloon technology to improve anchoring consistency in the gastrointestinal tract.

The PillarTM Technology are small nubs on the balloon that are made of silicone. The pillars create more friction, allowing doctors to better secure the device in the small intestine. Aspero Medical uses the micro-textured balloon in its AncoraTM Balloon Overtube for endoscopies.

Rieker’s company – LongPath Technology – has found success as well, recently being named the 2021 Colorado Photonics Company of the Year. LongPath uses laser technology to help oil and gas companies monitor methane and detect leaks across large areas of infrastructure.

The Frequency Comb Laser technology the company uses was the basis of Nobel Prize-winning research at the ��ƷSM��ӰƬ and the National Institute of Standards and Technology.

Tin Tin Su

Rentschler and Rieker are among the 63 inventors in the 2021 class of Senior Members. ��ƷSM��ӰƬ molecular, cellular and developmental biology professor Tin Tin Su is in this year’s class as well.

Su is the lead inventor on three issued patents, two of which are licensed to her startup company SuviCa, Inc. She now serves as the company's chief scientific officer. Su’s inventions have garnered $4.5 million in federal contracts from the National Cancer Institute, resulting in subcontracts to five Colorado researchers at other institutions and a potential new treatment for an orphan disease.

Currently, Su is utilizing a $2 million SBIR contract for SuviCa to develop an innovative screening platform–hardware and software–to identify novel radiation modulators for cancer. This system will be leveraged to generate intellectual property through partnership agreements to screen compound libraries. Each new compound identified has the potential to generate upwards of $4 million.

The NAI represents 37 research universities, government and non-profit research institutes. The 63 inventors are named on more than 625 issued U.S. patents. Rentschler, Rieker and Su are the first three inventors from ��ƷSM��ӰƬ to be inducted as Senior Members.

Inventors need to be nominated to receive the Senior Member standing with the NAI. Nominations are reviewed by the Senior Member Advisory Committee, a peer group comprised of NAI Fellows and Members.

The NAI includes more than 4,000 individual inventor members and fellows from more than 250 institutions around the world. Ten ��ƷSM��ӰƬ inventors have been named NAI Fellows since 2015.

Correction: The original article included Mollecular, Cellular and Developmental Biology Professor Tin Tin Su's name, but it did not include her photo and work. Both have been added to celebrate her accomplishments and value to the ��ƷSM��ӰƬ community.

Mechanical engineering Professors Mark Rentschler and Greg Rieker, as well as Department of Molecular, Cellular and Developmental Biology Professor Tin Tin Su, received the honor recognizing their thought-leadership and discovery on Monday, Nov. 1.

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ME professor to lead new I-Corps Hub at ��ƷSM��ӰƬ

Anonymous — Thu, 26 Aug 2021 20:30:38 +0000

ME professor to lead new I-Corps Hub at ��ƷSM��ӰƬ Anonymous (not verified) Thu, 08/26/2021 - 14:30

Along with seven collaborating research universities, ��ƷSM��ӰƬ will help boost tech innovation and launch startups with $15 Million award from the National Science Foundation.

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New medical balloon technology aims to improve endoscopy success

Anonymous — Tue, 24 Aug 2021 18:12:55 +0000

New medical balloon technology aims to improve endoscopy success Anonymous (not verified) Tue, 08/24/2021 - 12:12

Rachel Leuthauser

Above: Aspero's inflated balloon with Pillar^TM Technology
Below: Molding technology used to build medical balloon

Aspero Medical has received a patent for new technology that will help physicians diagnose and treat gastrointestinal illness more effectively. The medical device startup, cofounded by Paul M. Rady Department of Mechanical Engineering Professor Mark Rentschler, created a micro-textured medical balloon for endoscopies.

The new patent covers the startup company's Pillar^TMTechnology, the small nubs on the balloon made of silicone. The pillars are shaped and spaced out in a way that creates more friction, which allows doctors to secure the balloon in the small intestine. Medical balloons made by other companies are smooth and tend to slip in the mucus lining the intestine. Those balloons make endoscopies technically challenging and time-consuming.

"We feel like we're able to give better traction and better anchoring with less force," Rentschler explained. "Speed for the physician, deeper access for the patient, less trauma and full diagnosis and treatment that first time."

Balloon endoscopy is the standard to diagnose and treat small bowel disease. The balloon is inflated when inserted into the intestine, making room for a scope to move through. The procedure allows physicians to see the entire small intestine.

One of Rentschler’s goals is to “figure out a way to try to make a bigger impact with our discoveries at the bedside with the patient and the physician.” His new Pillar^TM Technology helps push that mission forward.

Engineering the micro-textured balloon

Companies have tried designing balloons with texture before, but not like this. Rentschler said the idea in the early 2000s was to use mesh around a balloon. When the balloon was inflated, it would squish through the holes of the mesh to create nubs intended to secure the balloon.

Rentschler's technology takes a more engineered approach using a molding design. Aspero Medical created a mold with pockets for each pillar. Silicone is injected into the mold and pushed into each hole.

“We wanted something super thin,” Rentschler said. “While we want the textures, we don’t want them to break. We want them to be as small as reasonably possible.”

While Rentschler pointed out that molding technology has improved in the last five years, the process to create such small pillars is not easy.

“In fall 2019, we started proving out our technology by transitioning to manufacturing and building our first micro-textured balloons at scale,” Rentschler explained. “That itself was a huge challenge. Most contract manufacturers wouldn’t even try to create these balloons with us because they didn’t think it was possible.”

Once Aspero Medical found a vendor ready for the challenge, the startup began building the balloons in spring 2020.

Rentschler created the Pillar^TM Technology with Dr. Steven Edmundowicz, Aspero Medical’s chief medical officer and the medical director of the Digestive Health Center at the University of Colorado Anschutz Medical Campus. The foundational intellectual property was developed at the University of Colorado. The CU Board of Regents owns the patent.

Utilizing the technology on medical products

Aspero Medical uses the micro-textured balloon in a product the company has lined up to submit for FDA approval.

The Ancora^TM Balloon Overtube attaches the pillared balloon to a silicone tube for endoscopies. Physicians move a scope through the silicone tube to visualize the digestive tract. Rentschler and Edmundowicz will apply for FDA approval this year. Rentschler said if all goes well, they expect approval three months after submitting. From there it’s commercialization.

Aspero Medical also plans to use the Pillar^TM Technology on a product for colonoscopy procedure. The company intends to submit that product for FDA approval in 2022. The Pillar^TM Technology is designed so that it could work with other balloons as well. That could include balloons used in cardiovascular or urology procedures.

“This product (Ancora Balloon Overtube) is for GI. Our second product is for colonoscopy, again GI,” Rentschler said. “We’re starting to put our heads together on what we think could be third.”

Professor Mark Rentschler's Boulder-based company will seek FDA approval after receiving a patent for its leading-edge medical balloon technology.

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Rentschler, Rieker named National Academy of Inventors Senior Fellows

Anonymous — Fri, 12 Feb 2021 15:55:08 +0000

Rentschler, Rieker named National Academy of Inventors Senior Fellows Anonymous (not verified) Fri, 02/12/2021 - 08:55

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Futurum partnership puts CU research in the hands of younger students

Anonymous — Thu, 04 Feb 2021 21:13:31 +0000

Futurum partnership puts CU research in the hands of younger students Anonymous (not verified) Thu, 02/04/2021 - 14:13

Sarah Kuta

A swallowable, remote-controlled robot that roams around inside a person’s intestines, using tools to perform procedures and sending back a live video stream of this funky pink environment? Now that’s some seriously cool science.

It’s hard to imagine a teenager who could resist exploring mechanical engineering after learning about Endoculus, the small device developed by ��ƷSM��ӰƬ Professor Mark Rentschler and student researchers in his lab that can navigate the human gastrointestinal system with ease and may someday help doctors care for their patients.

In fact, educators are hoping that middle and high school students are so intrigued by Rentschler and his sci-fi-esque robot that they pursue further study and maybe even a career in science, technology, engineering, math or medicine.

A comprehensive, teen-friendly article, activity sheet and PowerPoint presentation about Rentschler’s research are now available, free of charge, to teachers all over the world thanks to a partnership with Futurum, a United Kingdom-based organization that aims to help develop the next generation of scientists, engineers, mathematicians, researchers, doctors and beyond.

Download the Futurum lesson plans

Futurum helped translate Rentschler’s complex research into easy-to-digest (no pun intended) content that teachers can incorporate into their lesson plans and share with their students.

“Mark is a brilliant example of someone using his passion and knowledge to improve people’s lives,” said Brett Langenberg, Futurum’s founder. “His research is innovative — and the robotic element is cool — and has a real-life application that many young people will find inspiring. Mark’s work shows what can be achieved when you have aspirations, which is something we want all young people to have.”

The colorful and engaging online Futurum package also includes a question-and-answer interview with Rentschler, a CU engineering professor and Sylvia Norviel Cancer Research faculty fellow, about his path to becoming a mechanical engineer, the ins and outs of the field itself and some of Rentschler’s advice for young people.

Rentschler said he enjoyed the opportunity to think about his research through the eyes of a young person and reflect on his personal journey to becoming a scientist — from the tiny town of Atkinson, Nebraska, to the Massachusetts Institute of Technology and, eventually, to ��ƷSM��ӰƬ, with many other influential stops along the way.

He’s also glad that his research can serve as a real-world example of the types of fun, creative and potentially helpful projects students can work on if they pursue a career in STEM.

“One of our goals as faculty is to make a broad impact with our research, not only with the students that we’re directly training but also bringing the research to classrooms here at the university and even wider dissemination,” Rentschler said. “It’s a creative challenge to share your research with the broadest community possible, but this experience has demonstrated to me how you can distill your research into a tangible form for a younger audience.”

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Dynamic Mechanical Analyzer available to college in fall

Anonymous — Fri, 04 Sep 2020 14:29:30 +0000

Dynamic Mechanical Analyzer available to college in fall Anonymous (not verified) Fri, 09/04/2020 - 08:29

Researchers in the college will soon have access to a Dynamic Mechanical Analyzer testing platform. With it, they can perform mechanical load and displacement tests of materials, devices and components that were not possible previously.

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Mark Rentschler

Borden, Rentschler inducted into the AIMBE College of Fellows

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Rentschler, Aspero Medical awarded $4.5M for endoscopy advancement

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Faculty inducted as Senior Members of the National Academy of Inventors

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ME professor to lead new I-Corps Hub at ��ƷSM����ӰƬ

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New medical balloon technology aims to improve endoscopy success

Engineering the micro-textured balloon

Utilizing the technology on medical products

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Rentschler, Rieker named National Academy of Inventors Senior Fellows

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Futurum partnership puts CU research in the hands of younger students

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Dynamic Mechanical Analyzer available to college in fall

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ME professor to lead new I-Corps Hub at ��ƷSM��ӰƬ