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Changes in chromatin organization within the cell nucleus play a key role in the mechanical memory of cells

¾«Æ·SMÔÚÏßӰƬ researchers have made significant strides in understanding how cells adapt to their mechanical environment, a phenomenon known as mechanical memory. This knowledge is crucial for improving tissue regeneration procedures, such as cartilage repair.

Encouraging results include impressive selectivity and potency measures at the picomolar level

CU researchers have developed a portfolio of HDAC6-specific inhibitors. Encouraging results include impressive selectivity and potency measures at the picomolar level. Ongoing preclinical development at CU focuses on oncology applications, though neurodegenerative and inflammatory indications are also being explored.